pI: 6.9228 |
Length (AA): 1802 |
MW (Da): 201721 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
381 | 1321 | 1twf (A) | 241 | 1138 | 32.00 | 0 | 1 | 0.68 | 0.82 |
1545 | 1772 | 1jad (A) | 20 | 239 | 11.00 | 0.000083 | 0.01 | 0.07 | -0.08 |
6 | 1793 | 5xog (A) | 3 | 1453 | 25.00 | 0 | 1 | 0.817231 | 1.8 |
18 | 1792 | 4c2m (A) | 4 | 1662 | 30.00 | 0 | 1 | 1.00002 | 1.2 |
73 | 1791 | 4c2m (A) | 50 | 1664 | 35.00 | 0 | 1 | 0.92894 | 1.35 |
1129 | 1219 | 5szh (A) | 551 | 646 | 16.00 | 0 | 0.01 | 0.347799 | -1.61 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127924)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G57660 | nuclear RNA polymerase A1 |
Babesia bovis | BBOV_IV009600 | DNA directed RNA polymerase |
Brugia malayi | Bm1_43180 | RNA polymerase Rpb1, domain 2 family protein |
Candida albicans | CaO19.1839 | RNA polymerase I largest subunit |
Candida albicans | CaO19.9397 | RNA polymerase I largest subunit |
Caenorhabditis elegans | CELE_Y48E1A.1 | Protein RPOA-1, isoform B |
Cryptosporidium hominis | Chro.50318 | DNA-directed RNA polymerase |
Cryptosporidium parvum | cgd5_730 | DNA-directed RNA polymerase I, putative |
Dictyostelium discoideum | DDB_G0275759 | RNA polymerase I, largest subunit |
Drosophila melanogaster | Dmel_CG10122 | RNA polymerase I subunit |
Echinococcus granulosus | EgrG_001022100 | DNA directed RNA polymerase I subunit RPA1 |
Entamoeba histolytica | EHI_095890 | DNA-directed RNA polymerase I largest subunit, putative |
Echinococcus multilocularis | EmuJ_001022100 | DNA directed RNA polymerase I subunit RPA1 |
Giardia lamblia | GL50803_23496 | RNA polymerase AI large subunit |
Homo sapiens | ENSG00000068654 | polymerase (RNA) I polypeptide A, 194kDa |
Leishmania braziliensis | LbrM.16.1400 | DNA-directed rna polymerase I largest subunit, putative |
Leishmania donovani | LdBPK_161420.1 | DNA-directed rna polymerase I largest subunit, putative |
Leishmania infantum | LinJ.16.1420 | DNA-directed rna polymerase I largest subunit, putative |
Leishmania major | LmjF.16.1350 | DNA-directed rna polymerase I largest subunit, putative |
Leishmania mexicana | LmxM.16.1350 | DNA-directed rna polymerase I largest subunit, putative |
Loa Loa (eye worm) | LOAG_01639 | hypothetical protein |
Mus musculus | ENSMUSG00000049553 | polymerase (RNA) I polypeptide A |
Neospora caninum | NCLIV_019340 | DNA-directed rna polymerase I largest subunit, putative |
Oryza sativa | 9270399 | Os06g0612150 |
Plasmodium berghei | PBANKA_1109000 | RNA polymerase I, putative |
Plasmodium falciparum | PF3D7_0509400 | RNA polymerase I |
Plasmodium knowlesi | PKNH_1024200 | RNA polymerase I, putative |
Plasmodium vivax | PVX_098025 | DNA-directed RNA polymerase I 190 kDa polypeptide, putative |
Plasmodium yoelii | PY03255 | RNA polymerase A/beta'/A'' subunit, putative |
Saccharomyces cerevisiae | YOR341W | DNA-directed RNA polymerase I core subunit RPA190 |
Schistosoma japonicum | Sjp_0090080 | DNA-directed RNA polymerase I subunit RPA1, putative |
Schistosoma japonicum | Sjp_0090090 | DNA-directed RNA polymerase I subunit RPA1, putative |
Schistosoma japonicum | Sjp_0090100 | ko:K02999 DNA-directed RNA polymerase I subunit A1, putative |
Schistosoma japonicum | Sjp_0090070 | DNA-directed RNA polymerase I subunit RPA1, putative |
Schistosoma japonicum | Sjp_0021430 | DNA-directed RNA polymerase I subunit rpa1, putative |
Schistosoma mansoni | Smp_129500 | DNA-directed RNA polymerase I |
Schmidtea mediterranea | mk4.000030.02 | DNA-directed RNA polymerase I subunit RPA1 |
Schmidtea mediterranea | mk4.000030.03 | |
Schmidtea mediterranea | mk4.000030.00 | |
Trypanosoma brucei gambiense | Tbg972.8.4910 | DNA-directed rna polymerase I largest subunit, putative |
Trypanosoma brucei | Tb11.v5.0723 | DNA-directed rna polymerase I largest subunit, putative |
Trypanosoma brucei | Tb927.8.5090 | DNA-directed RNA polymerase I largest subunit |
Trypanosoma congolense | TcIL3000_8_4870 | DNA-directed rna polymerase I largest subunit, putative |
Trypanosoma cruzi | TcCLB.511381.40 | DNA-directed rna polymerase I largest subunit, putative |
Toxoplasma gondii | TGME49_244880 | DNA-directed RNA polymerase I RPA1 |
Theileria parva | TP01_0809 | RNA polymerase large subunit, putative |
Trichomonas vaginalis | TVAG_591230 | RNA polymerase A, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5090 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5090 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5090 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.5090 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YOR341W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1109000 | Plasmodium berghei | Essential | plasmo |
TGME49_244880 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | polymerase (RNA) I polypeptide A, 194kDa | Compounds | References |